Urinary coproporphyrin isomer distribution in the Dubin-Johnson syndrome.

Urinary coproporphyrinisomer distribution was studied in 13 patients suffering from the Dubin-Johnsonsyndromeand several control groups. In patients with the DubinJohnson syndrome the isomer distribution was quite the reverse to that of normal persons. The urinary isomer distribution was in the normal range in patients with Gilbert’s syndrome, hemolytic jaundice, and fatty liver. In many patients with different acute and chronic liver diseases,a clear deviation from the normal urinary isomer distribution was seen. There was, however, no overlapping with the DubinJohnson syndrome. Even the fecal coproporphyrin isomer distribution deviated significantly from the normal in favor of Isomer I.